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. Author manuscript; available in PMC: 2018 Jun 9.
Published in final edited form as: Pediatr Nephrol. 2007 Nov 30;23(2):221–231. doi: 10.1007/s00467-007-0636-6

Fig. 4.

Fig. 4

Human glomerular endothelial cells (HGECs) were exposed to tumor necrosis factor (TNF)-α (20 ng/ml) for 22 h and angiotensin II (Ang II) (10−8 M) for the last 4 h with or without incubation with an Ang II type I receptor (AT1R) inhibitor (losartan, 10−6 M) or AT2R inhibitor (PD 123319, 10−6 M) or their combination (10−6 M) for 22 h. Losartan and losartan in combination with PD 123319, but not PD 123319 alone, caused a statistically significant decrease in tissue factor (TF) activity induced by Ang II (n= 8 per experimental condition, median, 25th percentile, 75th percentile, and range, *P<0.05)