FIG. 2.
Targeted temperature is maintained with continuous IV infusion of CHA (0.25 mg/[kg·h]), indicated by shaded x-axis region; results are shown as mean ± SEM over 24 hours (n = 8). (A) Surface temperature was set to 17°C at start of CHA administration and increased to prevent overcooling; Tb over 24 hours was 33.2°C ± 0.3°C. (B) Surface temperature lowered to 17.1°C ± 0.1°C with vehicle administration resulted in a Tb of 37.7°C ± 0.1°C. (C) HR decreased to an average of 89 ± 4 bpm over 24 hours. (D) HR during vehicle administration remained within normal limits for the duration of the experiment.