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Acute hypoxic ventilatory responses are unaltered by the COX-2 inhibitor (NS-398) given systemically (A) or spinally (B). Systemic NS-398 (3 mg/kg, i.p.) group data (A) demonstrate no significant effect on the hypoxic response. Similarly, intrathecal NS-398 (27 mM) group data (B) show no significant effect on the hypoxic response.
