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. 2018 Jun 9;15:180. doi: 10.1186/s12974-018-1201-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Gut cytokines, plasma and CSF biochemistry, brain parameters in NEC versus No NEC pigs. a Daily physical activity expressed as percentage of active time starting on postnatal day 2. b Brain weight, c water content, d hippocampal weight comparison, and e expression of proinflammatory cytokine IL-1β, IL-6, IL-8 in the distal small intestine and the colon. f Total protein, albumin, lactate, and CRP in the plasma. g Total protein, lactate, and glucose in the CSF. Values are means ± SEMs, *p < 0.05; **p < 0.01; ***p < 0.001, versus No NEC pigs

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