Table 2.
Gene ontology analysis of differentially expressed genes associated with hepatocellular carcinoma.
| Expression | Category | Term | Count | % | P value | FDR |
|---|---|---|---|---|---|---|
| Downregulated | GOTERM_BP_DIRECT | GO:0019373~epoxygenase P450 pathway | 7 | 0.02 | 5.20E − 08 | 8.49E − 05 |
| GOTERM_BP_DIRECT | GO:0055114~oxidation-reduction process | 26 | 0.09 | 7.31E − 08 | 1.19E − 04 | |
| GOTERM_BP_DIRECT | GO:0071294~cellular response to zinc ion | 7 | 0.02 | 7.53E − 08 | 1.23E − 04 | |
| GOTERM_BP_DIRECT | GO:0045926~negative regulation of growth | 7 | 0.02 | 7.53E − 08 | 1.23E − 04 | |
| GOTERM_BP_DIRECT | GO:0042738~exogenous drug catabolic process | 6 | 0.02 | 1.95E − 07 | 3.19E − 04 | |
| GOTERM_CC_DIRECT | GO:0005576~extracellular region | 54 | 0.18 | 2.46E − 12 | 3.08E − 09 | |
| GOTERM_CC_DIRECT | GO:0005615~extracellular space | 44 | 0.14 | 1.19E − 09 | 1.49E − 06 | |
| GOTERM_CC_DIRECT | GO:0031090~organelle membrane | 12 | 0.04 | 5.53E − 09 | 6.91E − 06 | |
| GOTERM_CC_DIRECT | GO:0005887~integral component of plasma membrane | 41 | 0.14 | 1.42E − 07 | 1.77E − 04 | |
| GOTERM_CC_DIRECT | GO:0016323~basolateral plasma membrane | 12 | 0.04 | 9.02E − 06 | 0.01 | |
| GOTERM_MF_DIRECT | GO:0016705~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 10 | 0.03 | 2.41E − 08 | 3.42E − 05 | |
| GOTERM_MF_DIRECT | GO:0019825~oxygen binding | 9 | 0.03 | 8.01E − 08 | 1.14E − 04 | |
| GOTERM_MF_DIRECT | GO:0005506~iron ion binding | 13 | 0.04 | 3.31E − 07 | 4.70E − 04 | |
| GOTERM_MF_DIRECT | GO:0004497~monooxygenase activity | 9 | 0.03 | 4.36E − 07 | 6.19E − 04 | |
| GOTERM_MF_DIRECT | GO:0016712~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 6 | 0.02 | 6.52E − 07 | 9.26E − 04 | |
|
| ||||||
| Upregulated | GOTERM_BP_DIRECT | GO:0007067~mitotic nuclear division | 19 | 16.67 | 5.25E − 15 | 7.80E − 12 |
| GOTERM_BP_DIRECT | GO:0051301~cell division | 19 | 16.67 | 1.94E − 12 | 2.90E − 09 | |
| GOTERM_BP_DIRECT | GO:0007062~sister chromatid cohesion | 12 | 10.53 | 2.16E − 11 | 3.23E − 08 | |
| GOTERM_BP_DIRECT | GO:0007059~chromosome segregation | 8 | 7.02 | 1.44E − 07 | 2.16E − 04 | |
| GOTERM_BP_DIRECT | GO:0034501~protein localization to kinetochore | 4 | 3.51 | 2.31E − 05 | 0.03 | |
| GOTERM_CC_DIRECT | GO:0030496~midbody | 10 | 0.06 | 2.85E − 08 | 3.40E − 05 | |
| GOTERM_CC_DIRECT | GO:0000776~kinetochore | 8 | 0.05 | 2.45E − 07 | 2.93E − 04 | |
| GOTERM_CC_DIRECT | GO:0000777~condensed chromosome kinetochore | 7 | 0.04 | 6.94E − 06 | 0.01 | |
| GOTERM_CC_DIRECT | GO:0000775~chromosome, centromeric region | 6 | 0.03 | 1.29E − 05 | 0.02 | |
| GOTERM_CC_DIRECT | GO:0005871~kinesin complex | 5 | 0.03 | 1.81E − 04 | 0.22 | |
| GOTERM_MF_DIRECT | GO:0005515~protein binding | 72 | 63.16 | 4.54E − 06 | 0.01 | |
| GOTERM_MF_DIRECT | GO:0003777~microtubule motor activity | 5 | 4.39 | 0.001073553 | 1.34 | |
| GOTERM_MF_DIRECT | GO:0008017~microtubule binding | 6 | 5.26 | 0.006401849 | 7.77 | |
| GOTERM_MF_DIRECT | GO:0003682~chromatin binding | 8 | 7.02 | 0.006540341 | 7.93 | |
| GOTERM_MF_DIRECT | GO:0004693~cyclin-dependent protein serine/threonine kinase activity | 3 | 2.63 | 0.015639967 | 18.01 | |
GO: gene ontology; FDR: false discovery rate.