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. 2018 May 27;2018:9726950. doi: 10.1155/2018/9726950

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Copyright © 2018 Claudia Fuchs et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Altered ERK signaling pathway in Cdkl5 +/− female mice. (a) Western blot analysis of P-AKT-Ser 473 levels normalized to total AKT levels (left histograms) and P-ERK-Ser 42–44 levels normalized to total ERK levels (right histograms) in the hippocampus (a) and cerebellum (b) of Cdkl5 +/+ (n = 6 and n = 5, resp.), Cdkl5 +/− (n = 6 and n = 8, resp.), and Cdkl5 −/− (n = 6 and n = 5, resp.) mice. Immunoblots are examples from one animal of each experimental group. Data are expressed as a percentage of the values of Cdkl5 +/+ mice. Values are represented as means ± SE. ^∗ p < 0.05 and ^∗∗ p < 0.01 (Fisher's LSD after ANOVA).