Table 2.
Analysis of significant enrichment of DEGs in DLBCL.
| Term | Description | Count | P Value | Genes |
|---|---|---|---|---|
| Biological process | ||||
|
| ||||
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 10 | 0.008568 | BATF, SSBP2, LMO2, MAML3, IRF4, MYBL1, ETV6, TCF4, FOXP1, STAT3 |
| GO:0043066 | negative regulation of apoptotic process | 7 | 0.006042 | CFLAR, HSP90B1, CD44, CCND2, BCL2A1, PIM2, STAT3 |
| GO:0006954 | inflammatory response | 6 | 0.012073 | NFKBIZ, IL2RA, NLRP4, S100A8, CHST2, BLNK |
| GO:0050853 | B cell receptor signaling pathway | 3 | 0.016456 | IGHE, MNDA, IGHM |
| GO:0009967 | positive regulation of signal transduction | 3 | 0.020706 | STAP1, BLNK, SLA |
|
| ||||
| Cell component | ||||
|
| ||||
| GO:0005634 | nucleus | 28 | 0.081986 | CYB5R2, S100A8, LMO2, ITPKB, MYBL1, SFN, BATF, STAG3, LIMD1… |
| GO:0005737 | cytoplasm | 27 | 0.089649 | FUT8, MARCKSL1, EHHADH, MME, POSTN, SFN, BATF, ACTG2, CD44… |
|
| ||||
| Molecular function | ||||
|
| ||||
| GO:0005515 | protein binding | 43 | 0.027431 | CYB5R2, S100A8, LMO2, MARCKSL1, EHHADH, SPINK2, XK… |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 9 | 6.28E-05 | BATF, SSBP2, TGIF1, IRF4, MYBL1, ETV6, TCF4, FOXP1, STAT3 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 7 | 2.91E-04 | BATF, SSBP2, IRF4, MYBL1, ETV6, TCF4, STAT3 |
| GO:0005515 | protein kinase binding | 5 | 0.056821 | STAP1, CCND2, SPRED2, SFN, STAT3 |
| GO:0005070 | SH3/SH2 adaptor activity | 3 | 0.019671 | STAP1, BLNK, SLA |