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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Toxicol In Vitro. 2018 Mar 6;50:147–159. doi: 10.1016/j.tiv.2018.02.014

Fig. 9.

Fig. 9

One-way ANOVA analysis of IC50 values obtained from 3D-cultured Hep3B cells pre-incubated for 24 h and 72 h, exposed to menadione for 48 h, and stained with TMRM and mBCl for mitochondrial impairment and glutathione level (n= 3, ** p<0.01). Statistically significant difference in IC50 values of menadione was observed at the two pre-incubation conditions, indicating that increase in spheroid sizes reduce mitochondrial impairment and glutathione level-induced toxicity of menadione.