Analyzing the contribution of the NDM to the local production of selected gene expression with Pearson correlation coefficients that assess the interdependence between gene product diffusion and (5a) empirical atrophy or (5b) metabolism. Neither single genes (APP, MAPT, PRNP) or gene list (Transsynaptic, AD Associated, Metastable Subproteome, Aggregation Protector) appears to benefit from the contribution of the NDM.