. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Alzheimers Dement. 2018 Jan 4;14(6):797–810. doi: 10.1016/j.jalz.2017.11.014

Table 4.

NDM and Gene predictors of AD End-of-Study Pathology

Model	Predictors	Atrophy		Metabolism
Model	Predictors	R²	p-value for t-stat	R²	p-value for t-stat
a_AD = a + b * g_APOE + c * x(t_max)	NDM	0.32	1.66E-08	0.29	1.59E-06
a_AD = a + b * g_APOE + c * x(t_max)	APOE	0.32	0.39	0.29	0.017
a_AD = a + b * g_APP + c * x(t_max)	NDM	0.41	1.28E-09	0.27	1.09E-06
a_AD = a + b * g_APP + c * x(t_max)	APP	0.41	0.00080	0.27	0.044
a_AD = a + b * g_MAPT + c * x(t_max)	NDM	0.41	1.70E-08	0.36	1.58E-07
a_AD = a + b * g_MAPT + c * x(t_max)	MAPT	0.41	0.00061	0.36	0.00015
a_AD = a + b * g_PRNP + c * x(t_max)	NDM	0.38	5.94E-09	0.37	5.25E-08
a_AD = a + b * g_PRNP + c * x(t_max)	PRNP	0.38	0.0068	0.37	0.000080
a_AD = a + b * g_ADA + c * x(t_max)	NDM	0.41	4.42E-09	0.41	4.60E-08
a_AD = a + b * g_ADA + c * x(t_max)	AD Associated (ADA)	0.41	0.00046	0.41	3.93E-06
a_AD = a + b * g_RAGWAS + c * x(t_max)	NDM	0.32	1.90E-08	0.29	4.67E-07
a_AD = a + b * g_RAGWAS + c * x(t_max)	RAGWAS	0.32	0.84	0.29	0.0113
a_AD = a + b * g_T + c * x(t_max)	NDM	0.44	8.93E-09	0.45	1.18E-08
a_AD = a + b * g_T + c * x(t_max)	Transsynaptic (T)	0.44	6.55E-05	0.45	2.13E-07
a_AD = a + b * g_MS + c * x(t_max)	NDM	0.40	1.27E-09	0.36	3.95E-06
a_AD = a + b * g_MS + c * x(t_max)	Metastable Subproteome (MS)	0.40	0.0010	0.36	0.00020
a_AD = a + b * g_APM + c * x(t_max)	NDM	0.33	1.26E-08	0.26	1.27E-05
a_AD = a + b * g_APM + c * x(t_max)	Aggregation Promoter (APM)	0.33	0.35	0.26	0.12
a_AD = a + b * g_APT + c * x(t_max)	NDM	0.36	5.27E-09	0.30	4.20E-06
a_AD = a + b * g_APT + c * x(t_max)	Aggregation Protector (APT)	0.36	0.0070	0.30	.0071