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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Exp Neurol. 2018 May 2;306:105–116. doi: 10.1016/j.expneurol.2018.05.002

Fig. 5.

Fig. 5

DLF lesions switch how bicuculline affects nociceptive sensitization. (A) The experimental design used to examine how DLF lesions affect GABA function. Subjects received either DLF lesion (DLF; black) or sham surgery (Sham; white). A day after surgery, rats received either bicuculline (Bic; squares) or vehicle (Veh; circles). Fifteen min later, capsaicin was applied to the dorsal surface of one hind paw. (B) The impact of DLF lesions and drug treatment on mechanical reactivity in capsaicin-treated rats. The y-axis depicts the linearized mechanical scores [log 10 (10,000g)] as a change from baseline after bicuculline treatment (Post Drug), and 0, 1, 2, 3 hr after capsaicin treatment (Post Cap). Error bars depict ± SEM.