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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Exp Neurol. 2018 May 2;306:92–104. doi: 10.1016/j.expneurol.2018.05.001

Figure 5. Impairment of learning and memory in CNP;Cdk5 CKO mice.

Figure 5

(A) T maze test showed that CNP;Cdk5 CKO mice (8 weeks of age) spent significantly less time in blocked arm (n = 8 mice/group). (B) The passive avoidance test: CNP;Cdk5 CKO mice spent significantly less time in the dark compartment (n = 11–13 mice/group). (C) Fear conditioning test: CNP;Cdk5 CKO had significant lower levels of freezing in the context-dependent associative memory and cued-dependent memory tests (n = 8 mice/group). (D) Rotarod test: control mice showed a significant improvement in motor coordination while CNP;Cdk5 CKO mice did not (n = 13–23 mice/group). (E) No changes were seen in locomotor activities in an open field test. (F) Elevated plus maze: anxiety-like behavior was equivalent in CNP;Cdk5 CKO mice and controls (n = 7–11 animals/group). Values are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Two-way ANOVA with Sidak’s multiple comparisons test. n.s. = not significant.