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. 2018 Jun 4;9:1158. doi: 10.3389/fimmu.2018.01158

Figure 5.

Figure 5

Endoplasmic reticulum stress stimulation and cell death activation in the different brain regions are ascribable to gingival periodontal disease level-butyric acid (BA). Quantification of brain (A) GADD153 amounts, (B) calcium concentration, (C) caspase-1 activity, and (D) caspase-3 activity are indicated. Results shown are mean ± SE utilizing independent brain samples (hippocampus, pineal gland, hypothalamus, cerebrum, and cerebellum) of 10-week-old Wistar male rats (n = 6). Control and BA-treated (12 h post-treatment) rats were used. Statistical analyses were performed using Anderson–Darling normality test and, if passed (p > 0.05), Student’s t-test (**p < 0.01). Percent difference between control and BA-treated rats are labeled.