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. 2018 Jun 4;9:289. doi: 10.3389/fendo.2018.00289

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Copyright © 2018 Racine, Meadows, Ion and Serrat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increases in weight bearing and tibial elongation rate are correlated. Error bar plot shows that hindlimb weight bearing measured with an incapacitance tester (A) did not show significant left-right differences before the experiments. After 1-week heat-treatment, hindlimb weight bearing increased nearly 20% (>1 g) on the heat-treated side. Mean ± 1 SE plotted. Scatter plot (B) shows a significant positive linear relationship between the increase in weight bearing and increase in tibial elongation rate after 1 week of daily intermittent limb heating (y = 14.23 + 0.9x). Individual mice are plotted.