Skip to main content
. 2018 Jun 4;9:657. doi: 10.3389/fphys.2018.00657

Figure 3.

Figure 3

M2 pro-regenerative myeloid polarization accelerated by scaffolds is not directly dependent on TH2 cells. (A,B) TH2 signature genes expression (qRT-PCR) of (A) Jag2 and (B) IL4 displayed as a fold change over saline control at indicated weeks (n = 4–6 mice from two experiments). (C,D) TH1 signature genes expression (qRT-PCR) of (C) Ifnγ and (D) Tbx21 displayed as a fold change over saline control at indicated weeks (n = 4–6 mice from two experiments). (E) M2 signature genes expression (qRT-PCR) of Relmα and Arg1 displayed as a fold change over saline control at 2 weeks after wound treatment with N-ADM and single layer of N-ADM (S-N-ADM) (n = 4 mice from two experiments). (F) TH2 signature genes expression (qRT-PCR) of Jag2 and IL4 displayed as a fold change over saline control at 2 weeks (n = 4 mice from two experiments). (G) M2 signature genes expression (qRT-PCR) of Relmα and Arg1 displayed as a fold change over saline control at 2 weeks after wound treatment with collagen (n = 4 mice from two experiments). (H) TH2 signature genes expression (Real-time PCR) of Jag2 and IL4 displayed as a fold change over saline control at 2 weeks (n = 4 mice from two experiments). (I) TH1 signature genes expression (qRT-PCR) of Ifnγ and Tbx21 displayed as a fold change over saline control at 2 weeks (n = 4 mice from two experiments). ANOVA (A–F) and Student's t-test (G–I): *P < 0.05, **P < 0.01, ***P < 0.001.