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. 2018 Jun 4;9:657. doi: 10.3389/fphys.2018.00657

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Copyright © 2018 He, Yang, Jin, Qi, Chu and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Collagen accelerate M2 polarization in vitro with similar amounts of IL4. (A,B) In vitro flow cytometric analysis of macrophage (RAW 264.7) cell line treat with A-ADM or collagen (1 mg/ml) concurrently stimulated by 50 ng/ml IL4 (n = 4 from two experiment). CD206 = type-2 alternative macrophage. (C,D) Summary data for fraction of CD206⁺ macrophages. (E,F) M2 signature genes expression (qRT-PCR) of Relmα (E) and Arg1 (F) displayed as a fold change over control at 24 h after cell culture with A-ADM and collagen (n = 4 from two experiments). (G,H) M2 signature genes expression (qRT-PCR) of Relmα (G) and Arg1 (H) displayed as a fold change over control at 48 h (n = 5 from two experiments). ANOVA: ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.