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. 2018 Jun 4;9:580. doi: 10.3389/fphar.2018.00580

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Copyright © 2018 Gazzano, Lazzarato, Rolando, Kopecka, Guglielmo, Costamagna, Chegaev and Riganti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synthesis of designed TPP-derivatives and TPP-substituted phenols. Reagents and conditions: (i) R”COCl, Et₃N, CH₂Cl₂, 0°C, or Boc₂O, DMAP, CH₂Cl₂, 0 °C; (ii) NaBH₄, MeOH, 0 °C; (iii) NBS, PPh₃, CH₂Cl₂, 0 °C; (iv) PPh₃, toluene, reflux; (v) HBr 48% in MeOH, rt.