Table 1. Long-term survival in NSCLC with PD-1/PD-L1 inhibitors.
Drugs | Clinical trials | 2-year OS (%) | 3-year OS (%) | 5-year OS (%) |
---|---|---|---|---|
Pembrolizumab | Keynote 001 (treated native pts vs. previously treated pts) | 44.5 vs. 31.3 | 26.4 vs. 19.0 | Keynote 010 21.5 |
Nivolumab | CM017 (SQ) (Nivo vs. docetaxel) | 23.0 vs. 8.0 | 16.0 vs. 6.0 | CA209-003 SQ vs. non-SQ: 16.0 vs. 15.0 |
CM057 (non-SQ) (Nivo vs. docetaxel) | 29.0 vs. 16.0 | 18.0 vs. 9.0 | ||
Atezolizumab | OAK (Atezo vs. docetaxel) | 31.0 vs. 21.0 | – | – |
NSCLC, non-small cell lung cancer; Pts, patients; CM, checkmate; SQ, squamous lung cancer; non-SQ, non-squamous lung cancer; Nivo, nivolumab; Atezo, atezolizumab; OS, overall survival.