Table 2. Clinicopathological features and prognostic significance associated with PD-L1 expression in thymic epithelial tumors.
Studies | Factors associated with high PD-L1 expression | Prognostic impact of high PD-L1 expression |
---|---|---|
Padda et al. (13) | Younger age, high stage, incomplete resection, aggressive histology | Worse OS (age- and sex-adjusted analysis) |
Katsuya et al. (14) | Thymic carcinoma (rather than thymoma) | None |
Yokoyama et al. (15) | Masaoka stage III/IV, WHO type B2/B3 | Worse DFS |
Yokoyama et al. (16) | None | Better OS |
Marchevsky et al. (17) | Aggressive histology | – |
Weissferdt et al. (18) | Neoadjuvant therapy in thymoma | None |
Arbour et al. (19) | Thymoma (rather than thymic carcinoma) | Better OS |
PD-L1, programmed death ligand 1; WHO, World Health Organization; OS, overall survival; DFS, disease-free survival.