Table 3. The relations between GAB2 loci and CSF proteins in subgroup analysis at baseline.

CSF	SNP	CN				MCI				AD
		Sample	P	Pc*		Sample	P	Pc*		Sample	P	Pc*
Aβ (pg/mL)	rs1385600	206	0.0310	0.1240		377	0.0966	0.3865		44	0.5565	1
	rs1007837	206	0.0210	0.0841		377	0.1206	0.4823		44	0.5565	1
	rs10793294	206	0.1207	0.4828		377	0.3093	1		44	0.8932	1
	rs2373115	206	0.0765	0.3060		377	0.1027	0.4109		44	0.6173	1
T-tau (pg/mL)	rs1385600	205	0.0099	0.0398		374	0.1822	0.7287		41	0.8329	1
	rs1007837	205	0.0043	0.0172		374	0.2545	1		41	0.8329	1
	rs10793294	205	0.0161	0.0643		374	0.2166	0.8664		41	0.5301	1
	rs2373115	205	0.1108	0.4433		374	0.2883	1		41	0.6278	1
P-tau (pg/mL)	rs1385600	206	0.0012	0.0049		377	0.1968	0.7872		44	0.2182	0.8727
	rs1007837	206	0.0007	0.0027		377	0.4412	1		44	0.2182	0.8727
	rs10793294	206	0.0132	0.0527		377	0.2649	1		44	0.3145	1
	rs2373115	206	0.0169	0.0678		377	0.1614	0.6456		44	0.1879	0.7516

*, P value after Bonferroni correction. GAB2, growth factor receptor-bound protein-associated binding protein 2; CSF, cerebrospinal fluid; SNP, single nucleotide polymorphisms; CN, cognitively normal, MCI, mild cognition impairment, AD, Alzheimer’s disease; T-tau, total tau; P-tau, phosphorylated tau.