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. 2018 Jun 4;12:226. doi: 10.3389/fnhum.2018.00226

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Copyright © 2018 Stoessel, Stellmann, Willing, Behrens, Rosenkranz, Hodecker, Stürner, Reinhardt, Fleischer, Deuschle, Maetzler, Berg, Heesen, Walther, Schauer, Friese and Pless.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of altered metabolites using MetaboAnalyst shows perturbations in glycerophospholipid and linoleic acid pathways. Twenty significantly deregulated metabolites identified were subjected to MetaboAnalyst (Xia et al., 2015) to assess association of each metabolite with defined pathways. X-axis presents pathway impact values (based on relative-betweenness centrality) and the Y-axis presents the respective p-values (based on hypergeometric test). ^∗p-value ≤ 0.05 after FDR correction. The largest and significant impact was found in glycerophospholipid and linoleic acid pathways.