2.
Serum parameter | Correlation to liver fibrosis | Significance |
HA16 | Positive correlation | Accurately reflect the fibrosis and damage to the liver cells. Serum HA is slightly elevated with acute hepatitis, and significantly elevated with chronic active hepatitis, and extremely elevated with liver cirrhosis. |
PIINP17 | Positive correlation, but not specific | Is suitable for early diagnosis of liver fibrosis. |
Type IV collagen18,19 | Positive correlation | Usually diagnose early liver fibrosis and chronic liver disease |
Laminin20,21 | Positive correlation with fibrosis activity
and portal pressure |
Reflect degree of liver fibrosis. Elevated laminin (LN) content is also related to tumor invasion and metastasis. |