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. 2018 May;15(2):124–136. doi: 10.20892/j.issn.2095-3941.2018.0018

2.

The serum markers for diagnosis of liver fibrosis

Serum parameter Correlation to liver fibrosis Significance
HA16 Positive correlation Accurately reflect the fibrosis and damage to the liver cells. Serum HA is slightly elevated with acute hepatitis, and significantly elevated with chronic active hepatitis, and extremely elevated with liver cirrhosis.
PIINP17 Positive correlation, but not specific Is suitable for early diagnosis of liver fibrosis.
Type IV collagen18,19 Positive correlation Usually diagnose early liver fibrosis and chronic liver disease
Laminin20,21 Positive correlation with fibrosis activity
and portal pressure 		Reflect degree of liver fibrosis. Elevated laminin (LN) content is also related to tumor invasion and metastasis.