3.
Non-invasive diagnostic model for liver fibrosis
Model | Formula |
ALB: albumin; AST: aspartate aminotransferase; ALT: alanine transaminase; INR, international normalized ratio; GGT: gamma-glutamyl transferase; PLT: platelet; ULN: upper limit of normal; FibroQ: fibrosis quotient. | |
AAR26,27 | AST(IU/L) / AST(IU/L) |
APRI28 | AST(IU/L) / PLT(109/l) |
GPRI | GGT(IU/L) / PLT(109/l) |
S index | 1,000 × GGT (IU/L) / [PLT(109/l) × ALB2(g/L)] |
APRI29 | AST(IU/L) / ULN(IU/L) / PLT(109/l) |
FIB-4 score | [Age (years) × AST(IU/L)] / PLT (109/l) × ALT1/2 (IU/L) |
Fibro-Q | [10× AST(IU/L) × age (years) × INR] /
PLT (109/l) × ALT (IU/L) |
API
(Age plus PLT) |
Age (years): >70=5, 61–70=4, 51–60=3, 41–50=2, 31–40=1, ≤30=0 PLT (10 9/l): <125=5, 125–149=4, 150–174=3, 175–199=2, 200–224=1, ≥225=0 |
VITRO | von Willebrand factor antigen (vWF-Ag)/thrombocyte ratio |
APRG30 | ALP/PLT/RDW-SD/globulin |