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. 2018 Jun 4;9:1226. doi: 10.3389/fimmu.2018.01226

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Copyright © 2018 Deng, Fan, Gao, Zeng, Guo, Wei, Chen, Chen, Gong, Feng, Xia, Xiang, Gong, Yuan, Shen, Shen, Lin, Jiang, He, Lu, Chen and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Constitutive phosphorylation of signal transducer and activator of transcription 3 (STAT3) in CD4⁺ T cells from patients with rheumatoid arthritis (RA). The expression of intracellular phosphorylated STAT3 (pSTAT3) was analyzed using Phosflow assays in CD4⁺ T cells and B cells from RA patients. (A) FACS plots showing representative staining patterns for pSTAT3 (empty histograms) and an isotype control antibody (filled histograms) of indicated immune cell types; Numbers indicating the percentages of the pSTAT3 positive population. (B) Statistics showing the percentages of pSTAT3 positive population in total ZA⁻CD3⁻CD19⁺ viable B cells and ZA⁻TCRab⁺CD4⁺ viable CD4⁺ T cells from RA or HC groups. (C) FACS plots showing representative staining patterns for pSTAT3 and an isotype control antibody of indicated CD4⁺ T cell subsets; numbers indicating the percentages of the pSTAT3 positive population. (D) Statistics showing the percentages of pSTAT3 positive population in indicated CD4⁺ T cell subsets from RA or HC groups. Each dot represents the value of an individual subject with columns showing the mean value of each group. The p-values were obtained using Student’s t-tests.