Table 2:
Disease Characteristics and Genotype Counts by IBD Related Surgery
| Characteristic | IBD-related Surgery (n = 298) | No IBD-related Surgery (n = 310) | P-value |
|---|---|---|---|
| Disease Type | <2.2e-16 | ||
| CD | 248 (83.2%) | 152 (49%) | |
| UC | 50 (16.8%) | 158 (51%) | |
| Disease Duration | 12 +/- 16 | 7 +/- 10 | 1.36e-12** |
| Disease Location | <2.2e-16 | ||
| Large Bowel (including proctitis) | 72 (24.2%) | 189 (61%) | |
| Large Bowel + Small Bowel and/or Upper GI Disease | 176 (59.1%) | 90 (29%) | |
| Small Bowel (+/- Upper GI Disease) | 50 (16.8%) | 31 (10%) | |
| Disease Behavior (CD only, n = 400) | <2.2e-16* | ||
| Inflammatory | 24 (9.7%) | 105 (69.1%) | |
| Stricturing | 86 (34.7%) | 27 (17.8%) | |
| Fistulizing/Penetrating | 69 (27.8%) | 14 (9.2%) | |
| Fistulizing/Penetrating and Stricturing | 68 (27.4%) | 6 (3.9%) | |
| Fistulizing/Penetrating and Inflammatory | 1 (0.4%) | 0 | |
| CHRNA5 rs16969968 | 0.63 | ||
| AA | 36 (12.1%) | 32 (10.3%) | |
| AG | 129 (43.3%) | 145 (46.8%) | |
| GG | 133 (44.6%) | 133 (42.9%) |
* Fisher’s exact Test
** Wilcoxon Test