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Model of Oligonucleotide Release from an Intermediate Endomembrane Compartment. (1) Formation of ILVs by ESCRT-mediated budding from the compartment-limiting membrane. (2) Release of ILV contents to the cytosol by back fusion of ILVs with the limiting membrane. Oligonucleotide movement across membranes takes place at discontinuities located in nonbilayer regions as indicated by curved arrows. ESCRT, endosomal sorting complex required for transport; ILV, intraluminal vesicle.
