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. 2018 Jun 4;9:1172. doi: 10.3389/fimmu.2018.01172

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Copyright © 2018 Hovingh, de Maat, Cloherty, Johnson, Pinelli, Maas and Jongerius.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Various Bordetella pertussis strains activate the contact system. Contact system activation by B. pertussis strains B0442, B4418, B4430, B4393, and B4374 was shown by immunoblot. 50% plasma was incubated for 60 min with the B. pertussis strains (2 × 10⁹ CFU) and analyzed using anti-high-molecular-weight-kininogen (HK). Incubation with all the B. pertussis strains resulted in cleavage of the ~120 kDa full length HK as indicated by the appearance of the ~46 kDa cLC-HK chain.