Table 1. Summary of Japanese B. pertussis strains investigated by whole genome sequencing.
| Period | Total no. of isolates* | No. of locations | No. of ∆prn isolates | ∆prn mechanisms | Identified gene alleles | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| prn | ptxP | ptxA | fim2 | fim3 | fhaB | |||||
| 1981–1985 | 9 | 2 | 0 | mRNA↓† | 1 | 1 | 2 | 1 | 1 | 1 |
| 1986–1990 | 13 | 5 | 0 | – | 1 | 1, 8 | 1, 2 | 1 | 1 | 1 |
| 1991–1995 | 18 | 7 | 0 | – | 1, 2 | 1, 3 | 1, 2 | 1 | 1 | 1 |
| 1996–2000 | 42 | 11 | 8 | prn∆SS, prn :: IS481 | 1, 2 | 1, 3 | 1, 2 | 1 | 1 | 1 |
| 2001–2005 | 23 | 16 | 10 | prn∆SS, prn :: IS481 | 1, 2 | 1, 3, 8 | 1, 2 | 1 | 1, 2 | 1 |
| 2006–2010 | 43 (19) | 15 | 23 | prn∆SS, prn :: IS481 | 1, 2 | 1, 3 | 1, 2 | 1 | 1, 2, 4 | 1 |
| 2011–2014 | 40 (20) | 12 | 6 | prn∆SS | 1, 2 | 1, 3 | 1, 2 | 1 | 1, 2, 4 | 1 |
*The number of isolates from Konan Kosei is shown in parentheses.
†One isolate exhibited reduced prn mRNA production.