Figure 3.
TYW1 active site structure and models. (A) The binding pocket of KAC41 is shown, with interactions represented as dashed lines. (B) SAM molecule (slate) modeled in the active site with dashed lines indicating potential hydrogen bonds. The positions of classic SAM radical motifs are labeled. (C) m1G (teal) modeled into the active site with potential interacting residues shown as sticks. (D) The m1G (teal) modeled structure from panel C is shown in a different orientation with the dashed lines highlighting the distances between the sites of hydrogen atom abstraction.