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| Cytochrome P450 3A4 | P-glycoprotein | ||||
|---|---|---|---|---|---|
|
|
|
||||
| Drug | Substrate | Inhibitor | Potency | Substrate | Inhibitor |
| Fluconazole | Yes | Yes | + | Yes | No |
| Posaconazole | ND | Yes | ++to+++ | Yes | Yes |
| Voriconazole | Yes | Yes | +++ | No | No |
| Sirolimus | Yes | ND | ND | Yes | Yes |
| Tacrolimus | Yes | ND | ND | Yes | Yes |
ND: no data.
