Figure 2.

Scheme of PI3K/Akt/mTOR pathway depicting both complexes mTOR protein takes part in, mTORC1 and mTORC2. MTORC1 increases protein translation through phosphorylation of its two direct targets, 4EBP1 and P70S6K. While P70S6K induces protein translation through activation of the S6 ribosomal protein, 4EBP1 phosphorylation promotes protein synthesis by releasing eIF4E that can then bind to eIF4G to form, along with other proteins, the initiation complex eIF4F.