Skip to main content
. 2018 May 4;20(6):563–573. doi: 10.1016/j.neo.2018.04.003

Figure 3.

Figure 3

Mechanism of PI3K activation of mTOR proteins. Upon activation by transmembrane cell receptors, PI3K produces phosphatidylinositol trisphosphate (PIP3) from phosphatidylinositol biphosphate (PIP2), which PTEN reverses. PIP3 recruits proteins with pleckstrin homology domain such as PDK1 which phosphorylates Akt at Thr308. Akt phosphorylates and disrupts the complex Tuberous sclerosis complex 1/2 (TSC1-TSC2) which activates the GTPase activity of Rheb and phosphorylate and activate mTOR.