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Formation of the translation initiation complex eIF4F. Upon phosphorylation, 4EBP1 releases eIF4E, which binds to the 5′ PCa of the mRNA and brings to the scaffolding protein eIF4G that along with the mRNA helicase eIF4A forms the initiation complex eIF4F. Within this complex, the MAP kinase-interacting kinase (Mnk), which is phosphorylated by the P38 MAPK and ERK, is brought to proximity to its substrate eIF4E, phosphorylating it at Ser209.
