Table 1.
Drugs that affect the functioning of eIF4E.
| Drug | Target/action | Mechanism of inhibition of eIF4E |
|---|---|---|
| Galeterone | AR and CYP17A1 | Depletes Mnk protein expression causing suppression of eIF4E phosphorylation |
| VNPT55 | Galeterone analog | Depletes Mnk protein expression causing suppression of eIF4E phosphorylation |
| VNLG-152 | Dual AR/Mnk inhibitor | Prevents eIF4E phosphorylation |
| VNHM-1-81, VNHM-1-66 VNHM-1-73 | AR/Mnk degration inducers | Depletes Mnk protein expression causing suppression of eIF4E phosphorylation |
| Ribavarin | Guanosine analog | Inhibits eIF4E binding to m7G cap |
| 4EGI-1 | eIF4E/eIF4G interaction | Prevents eIF4E binding to eIF4G |
| Retinamides | Retinoic acid metabolism | Induce Mnk1/2 degradation |
| Ligustrazine | Anti-angiogenic | Decreases eIF4E phosphorylation, reduced eIF4E levels |
| C-KβBA | Anti-proliferative, pro-apoptotic | Inhibits cap-dependent translation |
| eFT508 | Mnk1/2 | Inhibits Mnk1/2 phosphorylation of eIF4E |
| BAY1143269 | Mnk1/2 | Inhibits Mnk1/2 phosphorylation of eIF4E |