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. 2018 May 3;20(6):555–562. doi: 10.1016/j.neo.2018.03.006

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Viability of MEFs and RPE-1 cells is partly restored by inhibition of LATS1/2. Cells were either transfected with siRNA Lats1/2, or with a nontarget siRNA (siNT). The influence of siRNA-mediated knockdown on cell growth was then monitored by WST-1 after incubation for two (MEF-wt) or three days (RPE-1) in the presence of AICAR. Results are representative of three independent experiments and are mean ± SD of triplicates. Relative cell proliferation was set at 100%, corresponding to the signal obtained with cells transfected with siNT. (ns, P > .05; *P < .05; **P < .01; ***P < .001).