Skip to main content
. 2018 May 3;20(6):543–554. doi: 10.1016/j.neo.2018.04.002

Figure 1.

Figure 1

STEAP3 expression is elevated in primary human GBM specimens. (A) Fold-change (log2) in mRNA levels of iron regulatory associated genes based on tumor pathology, GBM or LGG. Data was obtained from the TCGA dataset. (B) Analysis of STEAP3 mRNA levels (log2) in WHO grade II, grade III, and grade IV gliomas from the TCGA as a function of IDH mutation status. (C) STEAP3 mRNA expression (log2) in non-tumor brain samples and different histological subtypes of gliomas from the Rembrandt dataset. (D) STEAP3 mRNA expression (log2) across cancer cell lines from different tissues of origin. Glioma cell lines are highlighted in red. (E) Representative images of IHC staining for STEAP3 in normal brain and different pathological grades of astrocytomas showing cytoplasmic positivity. Magnification: 200×, upper panel; 400×, lower panel. (F) Scores for IHC staining represented in bar graphs. Five random fields from each section were counted. Data is shown as the mean ± the standard error of the mean (SEM) for each group. *P < .05, **P < .01, ***P < .001.