Figure 2.

High STEAP3 expression is a prognostic marker for poor clinical outcome in glioma patients. Kaplan–Meier analysis of patient survival data based on high vs low expression of STEAP3 in all gliomas (A), LGG (B), and GBM (C). The median value of STEAP3 expression was used as the cutoff in indicated databases. P-values were obtained from the log-rank test. (D) Correlation analysis was performed with TCGA GBM mRNA microarray data to obtain a set of STEAP3 associated genes. Cluster analysis was performed on STEAP3-associated genes based on STEAP3 expression. The resultant heatmap shows relative expression levels of STEAP3-associated genes in individual glioma cases where red is higher expression and blue is lower expression. (E) Biological processes and (F) Pathway analysis performed using the set of STEAP3-associated genes. Results are based the KEGG and GO databases.