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. 2018 May 15;20(6):632–642. doi: 10.1016/j.neo.2018.04.004

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Expression of CD25, CD26, and IL-1RAP on CD34⁺/CD38⁻ LSCs

A: Bone marrow (BM) cells from patients with Ph⁺ ALL with BCR/ABL1_p210 (upper panel), Ph⁺ ALL with BCR/ABL1_p190 (middle panel) or Ph⁻ ALL (lower panel) were stained with antibodies against CD34, CD38, CD45, CD25, CD26 and IL-1RAP. Expression of CD25, CD26 and IL-1RAP on CD45⁺/CD34⁺/CD38⁻ cells was analyzed by multicolor flow cytometry. The black open histograms show the isotype control and the red histograms represent CD25 (left panel), CD26 (middle panel) and IL-1RAP (right panel) expression on CD34⁺/CD38⁻ cells. B: qPCR analysis of expression of CD25 mRNA (upper panels), CD26 mRNA (middle panels) and IL-1RAP mRNA (lower panels) in CD34⁺/CD38⁻ cells and CD34⁺/CD38⁺ cells obtained from each 3 patients with Ph⁻ ALL (left panels), Ph⁺ ALL with BCR/ABL1_p190 (middle panels) or Ph⁺ ALL with BCR/ABL1_p210 (right panels). mRNA levels are expressed as percent of ABL1.