Table 2. Substrate scope of the combined photoredox/enzyme catalysis ^a .

Entry	Substrate	Photocat. & reducing agent	Biocat.	Product	Yield [e.e.] (%) b
1		Na3Ir(sppy)3(1 mol%) + AscH2 (0.2 M)	—		>95 c
2	1b	Na3Ir(sppy)3 (1 mol %) + AscH2 (0.2 M)	MAO-N-9 (180 mg)		>95 [98]
3		Na3Ir(sppy)3 (1 mol %) + AscH2 (0.2 M)	—		>95 c
4	1c	Na3Ir(sppy)3 (1 mol %) + AscH2 (0.2 M)	MAO-N-9 (180 mg)		>95 [8]
5		Na3Ir(sppy)3 (1 mol %) + AscH2 (0.2 M)	—		>95 c
6	1d	Na3Ir(sppy)3 (1 mol %) + AscH2 (0.2 M)	MAO-N-9 (180 mg)		>95 [>99]
7		Ru(bpy)3Cl2(1 mol %) + AscH2 (20 mM) + MPAA-PEG (10 eq.) + MPA-PEG (100 eq.)	—		>95 d
8	1e	Ru(bpy)3Cl2(1 mol %) + AscH2 (20 mM) + MPAA-PEG (10 eq.) + MPA-PEG (100 eq.)	MAO-N-9 (180 mg)		>95 [35] e

^aReaction conditions: 1 (10 mM), E. coli whole cells (MAO-N-9) (180 mg, wet weight), photocatalyst (1 mol%) and reducing agent as specified in each case, in 1.0 mL phosphate buffer solution (pH 8.0) at ambient temperature with 405 or 450 nm LED (3 W) irradiation on a shaking agitator (at 200 rpm, only used for reactions with biocatalyst) for 30 h under air.

^bYields were determined by ¹H NMR analysis, enantiomeric excess was determined by chiral phase GC or HPLC.

^c10 h.

^d3 h.

^e20 h.