Table 3.

Sensitivity analysis based on baseline blood pressure

	Baseline mean BP (±SD)		Number of trials	Reduction in BP (95% CI)	Interaction P-value
25% max
Systolic	147.3 ± 4.7	<147.3	6	10.03 (8.56–11.50)	0.63
		≥147.3	7	10.57 (8.94–12.20)
Diastolic	93.2 ± 4.1	<93.2	6	7.44 (6.77–8.12)	0.09
		≥93.2	7	6.27 (5.18–7.37)
50% max
Systolic	146.6 ± 7.3	<146.6	21	11.79 (10.55–13.04)	0.99
		≥146.6	28	11.78 (10.45–13.10)
Diastolic	90.1 ± 5.9	<90.1	19	7.22 (6.02–8.42)	0.56
		≥90.1	30	7.66 (6.92–8.59)
Max dose
Systolic	146.7 ± 7.8	<146.7	12	12.66 (11.62–13.70)	0.53
		≥146.7	23	13.32 (11.53–15.11)
Diastolic	90.3 ± 4.9	<90.3	16	7.90 (7.29–8.52)	0.20
		≥90.3	19	8.71 (7.61–9.80)

Interaction P-value comparing reduction in BP above and below baseline mean BP.

BP, blood pressure; CI, confidence interval; max, maximum; SD, standard deviation