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. 2018 Jun 4;9:1254. doi: 10.3389/fimmu.2018.01254

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Copyright © 2018 DellaValle, Manresa-Arraut, Hasseldam, Stensballe, Rungby, Larsen and Hempel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Full penetrance of experimental autoimmune encephalitis (EAE) induction in two models of multiple sclerosis. EAE was induced in C57Bl/6 mice with myelin oligodendrocyte glycoprotein (MOG-EAE) and in Lewis rats with myelin basic protein (MBP-EAE). (A) Clinical symptoms of increasing caudal–rostral CNS paralysis were significantly above zero from day 14 until peak disease. The experiment was terminated (day 20), coinciding with concomitant weight loss (B) in all mice that received MOG-EAE emulsion. MBP-EAE also induced clinical symptoms (C) and weight loss (D) in all rats receiving MBP-EAE emulsion. Data are presented as: (A) median with interquartile range; (B) average weight normalized to weight-before-emulsion (day −1); (C) dot blot of MBP-EAE rats included; (D) dot plot of weight normalized to weight-before-emulsion (day −1). Statistical differences were reported as *** or **** representing a p-value <0.001 and 0.0001, respectively, after testing for normality (Shaprio–Wilk) and equal variance and running the following statistical analysis: (A) Wilcoxon signed-rank test against the hypothetical value of 0; (B) two-way ANOVA; and (D) Student’s t-test. (A,B) N = control (6), MOG-EAE (9); (C,D) N = control (8) and MBP-EAE (10).