. Author manuscript; available in PMC: 2019 Mar 1.

Published in final edited form as: Dig Dis Sci. 2018 Feb 1;63(3):665–675. doi: 10.1007/s10620-017-4897-z

Table 2.

Serum Cr and Endogenous GFR Biomarkers Alternative to Cr in Patients with Cirrhosis

		Men		Women

		Mean Value	SD	Mean Value	SD	P Value

Serum Cr	Cr (mg/dL)	0.97	0.37	0.82	0.28	0.023

Measured Cr Production Rate	Measured Cr Production Rate (mg/kg/day)	13.37	5.60	11.02	3.85	0.022

Estimated Cr Production Rate¹	Estimated Cr Production Rate (mg/kg/day)	17.12	1.90	14.50	1.36	<0.0001

Measured GFR	Measured GFR (ml/min/1.73m²)	81.71	35.22	78.43	34.99	0.643

Estimated GFR²	Estimated GFR (ml/min/1.73m²)	80.73	28.05	76.27	22.86	0.393

Measured Cr Clearance	Measured Cr Clearance (ml/min/1.73m²)	78.75	40.76	77.37	41.08	0.874

Estimated Cr Clearance³	Estimated Cr Clearance (ml/min/1.73m²)	103.83	38.10	102.83	40.26	0.899

Endogenous GFR Biomarkers Alternative to Serum Cr	Cystatin C (mg/L)	1.18	0.50	1.16	0.38	0.811
	Beta-Trace Protein (mg/L)	1.00	0.56	0.94	0.43	0.597
	Beta-2 Microglobulin (mg/L)	4.13	2.17	3.92	1.86	0.618
	SDMA (micromole/L)	0.78	0.34	0.79	0.37	0.828
	ADMA (micromole/L)	0.69	0.21	0.62	0.14	0.076
	SDMA+ADMA (micromole/L)	1.47	0.48	1.42	0.44	0.615
	L-Arginine (micromole/L)	78.78	26.24	79.15	30.06	0.948
	L-Arginine/SDMA	115.80	57.81	116.26	56.12	0.968
	L-Arginine/ADMA	122.48	50.32	129.75	47.14	0.461
	L-Arginine/(SDMA+ADMA)	58.16	25.47	59.34	23.97	0.813

SD=Standard deviation.

Mitch and Walser equation³⁸ was used to calculate estimated Cr production rate.

Estimated GFR in ml/min/1.73m² using Cr-Cystatin C Equation for Cirrhosis²⁴=105.49 * (Cr ^−0.712) * (cystatin C ^−0.285) * (0.993^age) *(0.864^female) * (1.014^{African-American})

Estimated Cr clearance in ml/min/1.73m²= (Estimated Cr production rate in mg/kg/day using Mitch and Walser equation³⁸)*(weight in kg*100 ml)*(1.73 m²)/(serum Cr in mg/dl)*(1440 min)*(body surface area in m²).