Table 3.

Multivariate Models that included serum Cr, and GFR Biomarkers Alternative to Serum Cr controlled for Age, Race, Weight, Height and Measured GFR

Endogenous GFR Marker		Beta Coefficient for Female Gender*	Standard Error	P Value
Serum Cr	Cr (mg/dL)	−0.195	0.065	0.003
GFR Biomarkers Alternative to Serum Cr	Cystatin C (mg/L)	−0.130	0.094	0.169
	Beta-trace protein (mg/L)	−0.080	0.109	0.463
	Beta-2 microglobulin (mg/L)	−0.616	0.437	0.161
	SDMA (micromole/L)	−0.107	0.080	0.184
	ADMA (micromole/L)	−0.092	0.045	0.044

^*To determine the association of each endogenous GFR biomarker with female gender, a separate multivariate linear regression model was developed and controlled for age, race, weight, height and measured GFR. Female gender remained associated with lower serum Cr even after controlling for age, race, weight, height and measured GFR in 103 patients with cirrhosis.