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. Author manuscript; available in PMC: 2018 Jun 11.
Published in final edited form as: ACS Chem Neurosci. 2018 Feb 12;9(3):395–397. doi: 10.1021/acschemneuro.8b00044

Figure 2.

Figure 2

(A) Mn-PyC3A was a rationally designed as a direct GBCA replacement. The PyC3A ligand is constructed from a rigidifying N-picolyl-trans-1,2-diaminocyclohexane backbone (highlighted in green), which engenders a high degree of kinetic stability and the complex is thus highly resistant to degredation by Mn release. The Mn-PyC3A chelate also accommodates a rapidly exchanging water co-ligand (blue) that provides strong positive contrast to throughout the local tissue environment. The anionic charge (red) of Mn-PyC3A ensures extracellular distribution. (B and C) Multiplanar reformatted coronal images in baboons from 3D T1-weighted images acquired at 3.0 T showing the abdominal aorta and renal arteries (B) 9 seconds after injection of 0.1 mmol/kg Mn-PyC3A, and (C) 9 seconds after injection of 0.1 mmol/kg Gd-DTPA.