Table 1.
HDAC Inhibitory Activity of Compounds 9a–9o, and MS-275.
| |||||
|---|---|---|---|---|---|
| Compd | X | n | m | y | IC50 of HeLa nuclear extract (μM)a |
| 9a | −Br | 1 | 0 | 1 | 1.44 ± 0.42 |
| 9b | −Cl | 1 | 0 | 1 | 1.08 ± 0.08 |
| 9c | −F | 1 | 0 | 1 | 3.75 ± 0.65 |
| 9d | −Br | 0 | 0 | 1 | 2.66 ± 0.45 |
| 9e | −Cl | 0 | 0 | 1 | 2.17 ± 0.18 |
| 9f | −F | 0 | 0 | 1 | >6.00 |
| 9g | −Br | 1 | 1 | 1 | 2.00 ± 0.13 |
| 9h | −Cl | 1 | 1 | 1 | 1.25 ± 0.08 |
| 9i | −F | 1 | 1 | 1 | 1.56 ± 0.72 |
| 9j | −Br | 0 | 1 | 1 | 2.14 ± 0.73 |
| 9k | −Cl | 0 | 1 | 1 | 1.93 ± 0.34 |
| 9l | −F | 0 | 1 | 1 | 1.84 ± 0.62 |
| 9m | Br | 1 | 0 | 2 | 0.51 ± 0.03 |
| 9n | Cl | 1 | 0 | 2 | 0.43 ± 0.19 |
| 9o | Cl | 1 | 1 | 2 | 1.03 ± 0.25 |
| MS-275 | 1.12 ± 0.21 | ||||
a
Results expressed as the mean ± standard deviation of at least three separate determinations.