. Author manuscript; available in PMC: 2018 Jun 15.

Published in final edited form as: Bioorg Med Chem. 2017 Mar 19;25(12):2981–2994. doi: 10.1016/j.bmc.2017.03.036

Table 3.

HDAC Inhibitory Activity of Compounds 23a–23d, 30, and MS-275.


Compd	X	n	R₁	R₂	IC₅₀ of HeLa nuclear extract (μM)^a
23a	Cl	1		H	>100.0
23b	Cl	0		H	>100.0
23c	Cl	1		H	>100.0
23d	Cl	0		H	>100.0
30	Br	1	H	F	>100.0
MS-275					1.12 ± 0.21

Results expressed as the mean ± standard deviation of at least three separate determinations.