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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2017 Mar 19;25(12):2981–2994. doi: 10.1016/j.bmc.2017.03.036

Table 4.

In vitro antiproliferative activity for selected HDAC inhibitors.

Compd IC50 (μM)a
K562 Molt-4 HEL PC-3 SK-N-BE(2)
9a NDb ND 2.27 ND ND
9d 1.75 1.24 0.69 1.27 0.93
9h 2.83 2.46 1.15 11.35 1.92
9m 1.54 0.75 0.53 4.82 0.96
9n 1.48 0.70 0.58 3.23 1.01
23a 5.28 5.13 2.75 10.19 8.98
MS-275 1.32 0.65 0.48 4.89 0.33
a

Assays were performed in replicate (n ≥ 2), the SD values are <20% of the mean.

b

Not determined.