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HDAC class I and IIa cellular activity for selected HDAC inhibitors.a
| Compd | HDAC class I cellular IC50 (μM)b |
HDAC class IIa cellular IC50 (μM)c |
|---|---|---|
| 9a | >2.00 | >2.00 |
| 9d | 0.61 | >2.00 |
| 9h | 0.93 | >2.00 |
| 9m | 0.37 | >2.00 |
| 9n | 0.51 | >2.00 |
| 23a | >2.00 | >2.00 |
| MS-275 | 0.43 | >2.00 |
Assays were performed in replicate (n ≥ 2), the SD values are <20% of the mean.
Boc-Lys (acetyl)-AMC substrate.
Boc-Lys (triflouroacetyl)-AMC substrate.
