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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2017 Mar 19;25(12):2981–2994. doi: 10.1016/j.bmc.2017.03.036

Table 6.

HDACs inhibitory activity and isoform selectivity for selected HDAC inhibitors.

Compd IC50 of HDAC1 (μM)a IC50 of HDAC2 (μM)a IC50 of HDAC3 (μM)a HDAC2/HDAC1 isoform selectivity HDAC3/HDAC1 isoform selectivity
9d 0.046 0.128 0.667 2.8 14.5
9h 0.137 0.223 0.096 1.6 0.7
9m 0.012 0.026 0.019 2.2 1.6
9n 0.032 0.256 0.311 8.0 9.7
23a 0.023 0.179 151.8 7.8 6600
MS-275 0.163 0.396 0.605 2.3 3.7
a

Assays were performed in replicate (n ≥ 2), the SD values are <20% of the mean.