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. Author manuscript; available in PMC: 2018 Jul 7.
Published in final edited form as: Eur J Med Chem. 2017 Mar 30;134:185–206. doi: 10.1016/j.ejmech.2017.03.069

Table 1.

HDAC class I cellular activity and in vitro antiproliferative activity for synthesized HDAC inhibitors 3, 11a, 19, 22, 30a, 30b and 37.a

Cpd No. Structure IC50 of HDAC cellular class I (μM)b IC50 of HL60 cell (μM)
3 graphic file with name nihms968787t1.jpg 0.85 2.14
11a graphic file with name nihms968787t2.jpg 0.67 1.84
19 graphic file with name nihms968787t3.jpg 1.23 7.94
30a graphic file with name nihms968787t4.jpg 0.82 1.93
30b graphic file with name nihms968787t5.jpg >10 >20
22 graphic file with name nihms968787t6.jpg 1.75 5.97
37 graphic file with name nihms968787t7.jpg 2.95 8.04
MS275 graphic file with name nihms968787t8.jpg 0.62 1.52
a

Assays were performed in HL60 cells; Values are average of at least two determinations, the SD values are < 20% of the mean.

b

Boc-Lys (acetyl)-AMC substrate.